Genetic Insights into Circulating Complement Proteins in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Potential Inflammatory Subgroup - PubMed
8 days ago
- #genetics
- #ME/CFS
- #complement system
- Study investigates genetic drivers of complement system dysregulation in ME/CFS.
- Identifies an inflammatory subgroup with high C3/low Bb profile via pQTL analysis.
- Six pQTLs linked to fatigue-related phenotypes in UK Biobank, validating findings.
- Highlights genetic basis for complement dysregulation in a subset of ME/CFS patients.
- Suggests pathway-focused subgroups could inform personalized diagnosis and treatment.