Changes in the 6th edition of the World Health Organization classification of tumours of the digestive system - PubMed
9 hours ago
- #pathology
- #digestive system tumours
- #WHO classification
- The 6th Edition of the WHO Classification of Digestive System Tumours updates the 5th edition with new pathological, molecular, and clinical insights.
- Structural reorganization includes describing epithelial tumours by anatomical site and separating neuroendocrine, mesenchymal, and haematolymphoid tumours into dedicated chapters.
- New entities introduced include oesophageal epidermoid metaplasia, colorectal intramucosal adenocarcinoma, and sonic hedgehog hepatocellular adenoma.
- Grading systems are simplified to two-tier classifications (low/high grade) across precursor lesions.
- The classification emphasizes standardization in terminology, coding, and diagnostic criteria for global consistency.
- Carcinoma of unknown primary (CUP) is now included in a separate section, classified by molecular and immunophenotypic profiles.