CEBPB-Regulated Gastric Cell Plasticity Promotes Liver Metastasis of Gastric Cancer - PubMed
4 hours ago
- #CEBPB
- #gastric cancer
- #liver metastasis
- Liver metastasis is the most common distant spread in gastric cancer (GC) and remains difficult to manage.
- The study aimed to identify key molecular drivers of GC liver metastasis and potential therapeutic targets.
- Researchers used single-cell RNA sequencing, transcriptomics, epigenomics, and experimental validation.
- GC cells undergoing liver metastasis reprogram into a high plasticity state mediated by transcription factor CEBPB.
- CEBPB activates liver metastasis-associated genes through enhancer reprogramming.
- CEBPB-driven reprogramming enhances metastatic potential and immune evasion via CD155-TIGIT interaction.
- Blocking CD155-TIGIT interaction inhibits liver metastasis and restores T cell cytotoxicity.
- The CEBPB/CD155/TIGIT axis is identified as a promising therapeutic target for liver-metastatic GC.