Cerebral Ischemia-Reperfusion Injury: Unraveling the Mitophagy-Oxidative Stress Axis for Neuroprotective Strategies - PubMed
3 hours ago
- #mitophagy
- #oxidative stress
- #cerebral ischemia-reperfusion injury
- Cerebral ischemia-reperfusion (I/R) injury is a major contributor to neurological deterioration after ischemic stroke.
- The interaction between mitophagy and oxidative stress is a central regulatory axis in cerebral I/R injury.
- Moderate oxidative stress can activate protective mitophagy, aiding mitochondrial quality control and cellular homeostasis.
- Dysregulation of mitophagy or oxidative stress leads to a cycle of mitochondrial dysfunction and oxidative damage, worsening neuronal injury.
- The review discusses therapeutic strategies to modulate the mitophagy-oxidative stress axis for neuroprotection.
- Key pathways include AMPK/ULK1 signaling and cardiolipin externalization in mitophagy activation.