NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis - PubMed
3 hours ago
- #NUP85 signaling
- #liver fibrosis
- #endoplasmic reticulum stress
- NUP85 expression is elevated in liver fibrosis patients and mouse models.
- NUP85 knockdown reduces liver injury, collagen deposition, and endoplasmic reticulum stress (ERS), while overexpression worsens these effects.
- NUP85 competitively binds USP47 to ASK1, deubiquitinating ASK1 at lysine 805 to regulate its activation and exacerbate fibrosis and ERS.
- A CREKA-coupled liposome system delivers Mogroside V (MV), a NUP85 inhibitor, to activated hepatic stellate cells (HSCs) to attenuate liver fibrosis.
- The NUP85-USP47-ASK1 signaling pathway is identified as a potential therapeutic target for liver fibrosis intervention.