Gut microbiota contributes to gestational diabetes mellitus by interfering with bile acid metabolism and resistin - PubMed
8 hours ago
- #bile acid metabolism
- #gestational diabetes mellitus
- #gut microbiota
- Gut microbiota from GDM patients induces glucose intolerance in pregnant mice.
- Structural changes in gut microbiota include decreased Lachnospiraceae_FCS020_group and increased Akkermansia, Faecalibaculum, and Bilophila.
- Dysregulated microbiota leads to reduced intestinal barrier protein Claudin-1, elevated LPS, resistin, and MMP-9 levels.
- Metabolomic analysis shows decreased primary bile acids (CA, CDCA) and secondary bile acid DCA.
- Faecalibaculum positively correlates with DCA, CDCA, and resistin.
- DCA and CDCA negatively correlate with HOMA-IR; resistin positively correlates with GTT-AUC, FINS, and HOMA-β%.
- Gut microbiota imbalance in bile acid metabolism and mild inflammation drives GDM pathophysiology.