Polydisperse polystyrene microplastics exacerbate colitis through gut microbiota-butyrate-PPARγ axis disruption in mice - PubMed
4 hours ago
- #PPARγ
- #colitis
- #microplastics
- Polydisperse polystyrene microspheres (PS-MS) worsen colitis in mice by disrupting the gut microbiota-butyrate-PPARγ axis.
- PS-MS reduces Lachnospiraceae_NK4A136_group abundance and butyrate levels, impairing the mucus barrier and PPARγ signaling.
- Antibiotic treatment prevents PS-MS-induced colitis aggravation, while fecal microbiota transplantation from exposed mice transfers susceptibility.
- Sodium butyrate supplementation restores mucosal homeostasis via PPARγ activation, offering a potential therapy for IBD.
- The study highlights the microbiota-butyrate-PPARγ axis as a key target against microplastic-induced colitis.