ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance - PubMed
12 hours ago
- #genetic variants
- #autophagy
- #MGUS
- ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance (MGUS).
- MGUS is a precursor condition to multiple myeloma (MM), and autophagy-related genes were investigated for their role in MGUS susceptibility.
- A meta-analysis of 34,042 autophagy-related SNPs across six cohorts (2317 MGUS cases and 282,358 controls) identified a genome-wide significant association between the ULK4rs6599175C allele and increased MGUS risk.
- Carriers of the ULK4rs6599175C allele showed reduced counts of memory B cell subsets and natural effector B cells, suggesting a role in early B-cell differentiation.
- The CDKN2Ars2811710 variant showed a suggestive association with MGUS risk but lacked association with immune markers.
- The study supports the role of ULK4 in MGUS risk and identifies CDKN2A as a candidate susceptibility locus for further investigation.