Gut microbiome-produced bile acid metabolite lengthens the circadian period in host intestinal cells - PubMed
12 hours ago
- #bile-acids
- #circadian-rhythm
- #microbiome
- Gut microbiome-produced bile acid metabolite, lithocholic acid (LCA), lengthens the circadian period in host intestinal cells.
- LCA modulates the circadian period of core clock gene hPer2 transcription in human colonic cells in a dose-responsive manner.
- LCA affects the CK1δ/ε-PP1 feedback loop and stabilizes core clock protein CRY2.
- Feeding LCA alters circadian transcription in mouse distal ileum and colon.
- LCA serves as a molecular link between host circadian biology and the microbiome.
- Bile acids are secreted in response to feeding, providing insight into the food-entrainable oscillator (FEO).
- Findings may offer avenues for modulating host health related to circadian rhythm, feeding, and metabolic disease.