Toxoplasma gondii effector GRA35 mediates neuronal damage via er stress and mitochondria-associated apoptosis - PubMed
6 hours ago
- #Toxoplasma gondii
- #Apoptosis
- #Neuropathology
- Toxoplasma gondii effector GRA35 contributes to neuronal damage through ER stress and mitochondria-associated apoptosis pathways.
- GRA35 knockout strain (ME49Δgra35) reduces neuronal apoptosis compared to wild-type ME49, highlighting its role in promoting cell death.
- GRA35 interacts with RTN1-c to induce mitochondrial pathway-mediated apoptosis and triggers ER stress via the PERK signaling pathway.
- The findings identify GRA35 as a key virulence factor in Toxoplasmic encephalitis (TE), offering potential therapeutic targets for the disease.