Association of the endothelial activation and stress Index (EASIX) with cognitive function in United States older adults: Findings from NHANES 2011-2014 - PubMed
a day ago
- #cognitive decline
- #biomarkers
- #endothelial dysfunction
- The study explores the link between the Endothelial Activation and Stress Index (EASIX) and cognitive function in older adults.
- EASIX is calculated using routine lab measures: (creatinine × lactate dehydrogenase) / platelet count.
- Data from 2143 participants aged 60+ from NHANES 2011-2014 were analyzed.
- Cognitive tests included CERAD-WL, Delayed Recall, Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST).
- Higher EASIX scores were significantly associated with lower cognitive performance across multiple tests.
- EASIX showed strong associations with increased odds of cognitive dysfunction, particularly in AFT and DSST.
- The findings suggest EASIX could serve as a biomarker for cognitive aging and decline.