Antibody-mediated feedback modulates interclonal competition in the germinal center - PubMed
4 hours ago
- #vaccine design
- #germinal center
- #B cell
- Antibody-mediated feedback influences interclonal competition in germinal centers (GCs).
- A mouse model was developed to study the role of plasma cells (PCs) and antibodies in ongoing immune responses.
- Antibody feedback modulates competition between B cells with different epitope specificities.
- The study highlights implications for understanding immunodominance and vaccine design strategies.