Gut microbiota and renal fibrosis: novel mechanistic insights and therapeutic potential - PubMed
4 hours ago
- #gut microbiota
- #renal fibrosis
- #probiotics
- Gut microbiota dysbiosis occurs in both acute kidney injury (AKI) and chronic kidney disease (CKD).
- Dysbiosis involves damage to the intestinal barrier, reduced beneficial bacteria, and increased pathogens, affecting microbial-derived metabolites.
- Changes in metabolites like reduced short-chain fatty acids and accumulated uremic toxins (e.g., indoxyl sulphate, TMAO) worsen renal inflammation and fibrosis.
- Probiotics (e.g., Parabacteroides goldsteinii, Lactobacillus johnsonii) can attenuate renal fibrosis by modulating key signaling pathways via metabolites.
- Targeting gut microbiota through probiotics, natural products, and fecal microbiota transplant shows therapeutic potential against renal fibrosis.