Betulin inhibits inflammatory factors synthesis in osteoarthritis synovial fibroblasts by suppressing the PI3K, Akt, and mTOR pathways and activating miR-5006-5p - PubMed
6 hours ago
- #Betulin
- #Osteoarthritis
- #Inflammation
- Betulin, extracted from birch trees, inhibits inflammatory factors CHI3L1 and ICAM-1 in osteoarthritis synovial fibroblasts (OASFs).
- Levels of CHI3L1 and ICAM-1 are higher in OA patients and ACLT-induced OA rats compared to healthy individuals.
- Betulin works by suppressing the PI3K, Akt, and mTOR pathways and activating miR-5006-5p to reduce inflammation.
- Molecular docking analysis predicts direct interaction between betulin and CHI3L1/ICAM-1, suggesting potential for OA management.