miR-199a-3p Promotes Adipogenic Differentiation to Aggravate Steroid-Induced Osteonecrosis of Femoral Head via the ITGB8/FAK-ERK/RUNX2 Pathway - PubMed
3 hours ago
- #ITGB8
- #miR-199a-3p
- #SONFH
- miR-199a-3p is identified as a key regulator in steroid-induced osteonecrosis of the femoral head (SONFH).
- miR-199a-3p promotes adipogenic differentiation (AGD) and suppresses osteogenic differentiation (OGD) in bone marrow mesenchymal stem cells (BMSCs).
- The study reveals that miR-199a-3p targets integrin β8 (ITGB8), leading to inactivation of the FAK-ERK-RUNX2 signaling pathway.
- Silencing miR-199a-3p restores ITGB8 levels and reactivates the FAK-ERK-RUNX2 pathway, correcting the OGD/AGD imbalance.
- In vivo experiments show that antagomiR-199a-3p improves bone architecture and increases bone mass in a SONFH rat model.
- The findings suggest miR-199a-3p/ITGB8-FAK-ERK-RUNX2 axis as a potential therapeutic target for early intervention in SONFH.