Liver Sinusoidal Endothelial Cells and Laminin dictate cholangiocytes' fate in chronic liver disease - PubMed
3 hours ago
- #chronic liver disease
- #liver regeneration
- #extracellular matrix
- Study explores how Liver Sinusoidal Endothelial Cells (LSECs) and laminin influence cholangiocyte fate in chronic liver disease, affecting regeneration.
- Identified two ductular reaction (DR) cell populations: Lam-DRs (surrounded by laminin) retain biliary phenotype, while NoLam-DRs show increased hepatocyte marker Hnf4α expression.
- Capillarized CD34+ LSECs promote laminin deposition, which prevents DR cell differentiation into hepatocytes, limiting liver regeneration.
- Preventing LSEC capillarization in mice reduced laminin, enhanced DR-to-hepatocyte differentiation, and this LSEC-laminin-DR complex was found in human liver disease samples.
- Targeting LSEC capillarization or laminin could be a therapeutic strategy to improve liver regeneration in chronic liver diseases.