LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis - PubMed
3 hours ago
- #Sepsis
- #Ferroptosis
- #Acute Lung Injury
- LCN2 plays a key role in aggravating sepsis-induced acute lung injury (ALI).
- The mechanism involves inhibition of MUC1, leading to activation of ER-stress-autophagy induced ferroptosis via the lactate/MCT1/AMPK/mTOR axis.
- Sorafenib was identified as a potential therapeutic compound for ALI, improving survival rates and alleviating lung injury in septic mice.
- The study utilized various methods including Western blot, Immunohistochemistry, HE staining, TEM, and lipid peroxidation activity detection.
- Findings suggest new therapeutic targets and strategies for sepsis-induced ALI.