FOXJ1 mediates taxane resistance through regulation of microtubule dynamics - PubMed
7 days ago
- #taxane resistance
- #microtubule dynamics
- #prostate cancer
- FOXJ1 mediates taxane resistance in prostate cancer by regulating microtubule dynamics.
- Increased FOXJ1 expression is linked to docetaxel resistance in prostate cancer patient-derived xenografts.
- FOXJ1 overexpression decreases docetaxel-mediated microtubule bundling, contributing to resistance.
- Knockdown of FOXJ1 enhances taxane binding to microtubules and increases docetaxel sensitivity.
- FOXJ1 gene amplification is observed in taxane-treated prostate cancer patients.
- Higher baseline FOXJ1 levels predict decreased survival in docetaxel-treated metastatic prostate cancer patients.
- The findings suggest FOXJ1 as a potential biomarker for taxane resistance stratification.