Control of lysosome function by the GTPase-activating protein TBC1D9B and its binding partner TMEM55B - PubMed
3 hours ago
- #lysosome
- #GTPase
- #autophagy
- Lysosomes serve dual functions as catabolic stations for macromolecule degradation and as metabolic decision centers for growth signaling.
- TBC1D9B is identified as a critical negative regulator of ARL8B, a small GTPase controlling lysosome dynamics.
- TBC1D9B associates with TMEM55B, binds to ARL8B-GTP, and stimulates its GTPase activity.
- Knockout of TBC1D9B or TMEM55B leads to lysosome dispersion, defective autophagic flux, and impaired nutrient response.
- Lysosomal defects from TBC1D9B loss are mitigated by ARL8 depletion, highlighting their regulatory relationship.