Transforming growth factor β induced as a novel secreted immune checkpoint counterinhibiting human tumor-associated T cells - PubMed
4 hours ago
- #Secreted Immune Checkpoint
- #Cancer Immunotherapy
- #TGFBI
- TGFBI (Transforming growth factor β induced) is a novel secreted immune checkpoint that inhibits human tumor-associated T cells.
- Elevated serum TGFBI levels in colorectal and hepatocellular carcinoma patients correlate with poor survival outcomes.
- TGFBI is expressed by various cell types in tumors, including T cells, B cells, NK cells, monocytes, and tumor cells.
- Neutralizing TGFBI enhances T cell activation, differentiation into effector cells, and tumor-killing ability in experiments.
- TGFBI creates an autocrine immunosuppressive loop in T cells, limiting their anti-tumor function.
- Blocking TGFBI improves cytotoxic T cell expansion and tumor cell killing in colorectal cancer organoid models.
- Findings suggest TGFBI blockade could be a promising immunotherapy strategy for solid tumors.