Androgen receptor splice variant 7 expression levels distinguish AR-mutated from nonmutated metastatic castration-resistant prostate cancers - PubMed
10 hours ago
- #androgen receptor
- #biomarker
- #prostate cancer
- AR-mutated mCRPC expresses lower AR-V7 protein than nonmutated mCRPC.
- Lower AR-V7 in AR-mutated mCRPC correlates with better survival and ARPI sensitivity.
- This may be due to splicing factor differences, not total splicing changes.
- AR mutation status could predict response to AR-directed therapies.