Long-Term Outcomes and Recovery Trajectories in Out-of-Hospital Cardiac Arrest: A 2-Year Follow-Up of the Randomized Clinical TTM2 Trial - PubMed
6 days ago
- #cardiac arrest
- #hypothermia
- #recovery
- The study investigated the long-term effects of targeted hypothermia versus targeted normothermia on functional and cognitive outcomes in out-of-hospital cardiac arrest (OHCA) survivors over 24 months.
- No significant differences were found between the two temperature control groups in terms of societal participation or cognitive function at the 24-month follow-up.
- Improvement in functional outcomes, as measured by the Glasgow Outcome Scale-Extended (GOSE), was significant within the first 6 months but plateaued thereafter.
- Intraindividual variability in recovery trajectories was observed, indicating that some patients continued to improve or decline in societal participation and cognitive function up to 24 months post-arrest.
- The findings suggest that targeted hypothermia does not have a longer-term effect on the explored outcomes compared to targeted normothermia with early fever treatment.