Changes of Helicobacter pylori Infection Status and Risk of Precancerous Lesions: A Prospective Cohort Study in Chinese Population - PubMed
5 days ago
- #precancerous lesions
- #Helicobacter pylori
- #gastric cancer
- Study evaluates associations between Helicobacter pylori infection status changes and precancerous gastric lesions (PGLs) risk.
- Analysis of 6208 participants from the FuSion cohort with gastroscopy and H. pylori antibody data.
- Participants classified into four ABC groups based on H. pylori IgG antibodies and pepsinogens (PG).
- Increasing trend in PGLs prevalence and severity observed across ABC groups (p for trend < 0.05).
- Graded risk increases for PGLs noted from consistently negative to remained positive groups.
- Seroreverted participants still had elevated risks of atrophic gastritis (aOR = 2.01) and intestinal metaplasia (aOR = 1.72).
- Long-term H. pylori exposure linked to higher PGLs risk, persisting even after seroreversion.