Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas - PubMed
5 hours ago
- #Targeted Therapy
- #Somatostatin Receptor 2
- #SDHB-deficient PPGL
- SSTR2 and SSTR1 are predominantly expressed in PPGL, regardless of molecular cluster.
- Selective SSTR2 agonist BIM-23120 reduces proliferation and induces apoptosis only in SDHB-deficient PPGL cells.
- BIM-23120 causes dephosphorylation of key proliferation and survival pathways, unlike octreotide.
- SSTR2 shows stronger membrane expression and internalization in SDHB knockdown cells upon BIM-23120 treatment.
- Conventional somatostatin analogs (e.g., octreotide, pasireotide) lack clear antitumoral effects in PPGL models.
- The study identifies SSTR2 as a specific vulnerability for SDHB-deficient PPGL, suggesting potential new therapeutics.