Osteoarthritis: molecular pathogenesis and potential therapeutic options - PubMed
9 hours ago
- #Osteoarthritis
- #Therapeutic Options
- #Molecular Pathogenesis
- Osteoarthritis (OA) is a debilitating joint disorder causing chronic pain, inflammation, and bone alterations.
- Current OA treatments are inadequate in halting disease progression or providing effective pain relief.
- Key drivers of OA progression include mitochondrial dysfunction, lysosomal destabilization, and unresolved ER stress.
- Recent research highlights nociceptive pathways linking the knee joint to the central nervous system.
- Pathological changes in bone architecture and chondrocytes are influenced by inflammatory cytokines and organelle dysfunctions.
- Emerging pharmacological strategies aim to address inflammation, restore organelle homeostasis, and attenuate nociceptive signaling.
- Advanced organelle-targeted drug delivery systems are being developed to enhance treatment efficacy and stability.
- These advancements provide a framework for novel OA interventions targeting both structural degeneration and clinical symptoms.