Spatiotemporal molecular profiling of macrophage-fibroblast crosstalk defines checkpoints orchestrating onset and resolution of inflammation - PubMed
4 hours ago
- #macrophage-fibroblast crosstalk
- #arthritis
- #inflammation
- Macrophage-fibroblast crosstalk is crucial for the onset and resolution of inflammatory arthritis.
- Single-cell RNA sequencing and chromatin accessibility data reveal distinct synovial macrophage and fibroblast subsets.
- Pro-inflammatory Il1b+ macrophages dominate early inflammation and later differentiate into Spp1+ macrophages.
- Spp1+ macrophages suppress fibroblast activation and promote resolution via mediators like osteopontin.
- The study highlights the dual role of macrophages in both perpetuating and resolving inflammation.