Neuropeptide Y co-opts neuronal ensembles for memory lability and stability - PubMed
7 hours ago
- #neuropeptide Y
- #memory extinction
- #interneurons
- Neuropeptide Y (NPY)-expressing GABA-ergic interneurons in ventral CA1 regulate memory acquisition and extinction in mice.
- NPY release increases during extinction learning, correlating with a shift from fear-on to fear-off behavioral states.
- NPY acts on distinct neuronal subensembles expressing NPY1R and NPY2R receptors to control early fast and late slow extinction stages.
- Subtype-specific, slow peptidergic inhibition from interneurons determines engram lability versus stability.