Long-term risk of dementia with angiotensin receptor blockers versus angiotensin-converting enzyme inhibitors in hypertensive patients: A 15-year follow-up using the 45 and Up Study - PubMed
3 hours ago
- #pharmacology
- #hypertension
- #dementia
- Study compares dementia risk in hypertensive patients using ARBs vs. ACEIs over 15 years.
- ARB use linked to significantly reduced dementia risk compared to ACEIs (HR = 0.72).
- Specific ARBs like olmesartan, candesartan, telmisartan, irbesartan, and perindopril showed lower dementia risk vs. lisinopril.
- Captopril (an ACEI) was associated with a higher dementia risk (HR = 4.9).
- Results remained consistent across subgroup and sensitivity analyses.
- Findings suggest ARBs may play a role in dementia prevention, but further RCTs are needed.