Mitochondria serve as a source of mineral precursors initiating early cartilage calcification in osteoarthritis - PubMed
3 hours ago
- #Mitochondria
- #Osteoarthritis
- #Calcification
- Mitochondria are identified as sources of mineral precursors (calcium and phosphorus) that initiate early cartilage calcification in osteoarthritis.
- Chondrocyte mitochondrial DNA (mtDNA) transforms into an intertwined state to stabilize minerals into amorphous precursors during early osteoarthritis.
- These mineral precursors are transported via vesicles to the mineralization site, contributing to pathological cartilage calcification.
- Modulating CHCHD6 can inhibit mtDNA distribution, thereby reducing cartilage calcification and slowing osteoarthritis progression.
- The study provides new insights into mitochondrial-driven calcification, offering potential therapeutic targets for early osteoarthritis treatment.