Mitochondria-Targeted Liposomes Boost Thermogenesis for Adipose Tissue Regulation - PubMed
3 hours ago
- #obesity therapy
- #thermogenesis
- #mitochondrial targeting
- Mitochondrial dysfunction and oxidative stress are key factors in obesity, making mitochondrial targeting a promising therapeutic strategy.
- AE@PEP-Lip liposomes are designed for adipose mitochondrial targeting with a positively charged surface for accumulation in white adipose tissue.
- The SS-31 peptide in AE@PEP-Lip scavenges mitochondrial reactive oxygen (mROS) and synergizes with empagliflozin to inhibit mitochondrial fragmentation.
- Allicin in AE@PEP-Lip activates the AMPK pathway, upregulates uncoupling proteins, and promotes mitochondrial thermogenesis.
- In obese mice, AE@PEP-Lip improved mitochondrial morphology, function, and induced browning of adipose tissue.
- A porcine model demonstrated AE@PEP-Lip's potential for clinical application in reducing localized fat deposition.