S100A8/A9 as a central hub in inflammaging: Cross-system mechanisms - PubMed

8 hours ago

S100A8/A9 is a central hub in inflammaging, linking chronic inflammation to aging-related pathology.
It functions extracellularly by promoting leukocyte adhesion and myeloid-derived suppressor cell aggregation, and intracellularly by regulating inflammasomes, metabolism, autophagy, and apoptosis.
S100A8/A9 plays roles across multiple systems: promoting immunosuppression in tumors, neuroinflammation in the nervous system, endothelial aging in cardiovascular disease, metabolic dysfunction, and muscle atrophy.
Elevated S100A8/A9 serves as a biomarker for disease diagnosis, risk stratification, and imaging, correlating with therapeutic resistance and poor outcomes.
Targeting the S100A8/A9-TLR4 axis or neutralizing S100A9 shows potential in animal models to reduce inflammation and delay disease progression.

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