Phagocytosis of necroptotic cells optimizes type 1 conventional dendritic cells for induction of a cytotoxic T-cell response - PubMed
4 hours ago
- #dendritic cells
- #immunology
- #necroptosis
- Phagocytosis of necroptotic cells enhances type 1 conventional dendritic cells (cDC1s) for cytotoxic T-cell response induction.
- cDC1s excel at antigen cross-presentation, crucial for CD8+ cytotoxic T-lymphocyte (CTL) responses.
- Apoptotic cell debris induces a homeostatic maturation state in cDC1s, leading to T-cell non-responsiveness.
- Necroptotic cell debris is more immunogenic than apoptotic debris, inducing a specific maturation state in cDC1s.
- Necroptosis triggers a transcriptomically defined cDC1 state, enhancing cytokine signaling, metabolic activity, and functional differentiation.
- The study suggests using the cDC1 signature to diagnose necroptosis immunogenicity ex vivo.