Metabolic interactions in the brain: the crucial roles of neurons, astrocytes, and microglia in health and disease - PubMed
2 days ago
- #neurodegenerative diseases
- #cellular interactions
- #brain metabolism
- Neurons rely on oxidative phosphorylation and the TCA cycle for energy to support synaptic activity and neurotransmitter synthesis.
- Astrocytes primarily use glycolysis, producing lactate and glutathione, which are vital for neuronal function and oxidative stress protection.
- Microglia exhibit metabolic flexibility, switching between oxidative phosphorylation and glycolysis based on their activation state, affecting neuroinflammation and synaptic plasticity.
- Astrocyte-neuron metabolic coupling, through mechanisms like the lactate shuttle and glutathione metabolism, is crucial for neuronal homeostasis and synaptic function.
- Disruptions in brain energy metabolism are linked to neurodegenerative diseases such as Alzheimer's, Parkinson's, and ALS, highlighting potential therapeutic targets.
- The review emphasizes the importance of understanding brain energy metabolism in both health and disease for advancing neurology research.