Targeting the gut microbiota as treatment for obesity and cancer cachexia - PubMed
4 hours ago
- #precision medicine
- #metabolic disorders
- #gut microbiome
- Obesity and cancer cachexia are metabolic disorders with disrupted energy homeostasis, inflammation, and neuroendocrine dysfunction.
- The gut microbiome plays a significant role in the pathophysiology of both conditions and is a potential therapeutic target.
- Shared and distinct pathways in obesity and cancer cachexia involve the gut-brain axis, skeletal muscle, and adipose tissue metabolism.
- Gut microbial metabolites influence signaling pathways, affecting disease progression.
- Current treatments for obesity and cachexia have limitations, prompting exploration of microbiome-targeted therapies like prebiotics, probiotics, postbiotics, and fecal microbiota transplantation.
- Precision medicine approaches based on microbial and metabolic profiles could enhance treatment efficacy.
- Further research is needed to understand mechanistic pathways and develop engineered microbiota therapies.