Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin - PubMed
4 hours ago
- #fibronectin
- #wound-healing
- #macrophages
- Peritoneal macrophages (LPMs) regulate distant wound healing through endocrine release of plasma fibronectin.
- LPMs do not migrate to wound sites but secrete fibronectin, which accelerates healing remotely.
- Depletion of LPMs or fibronectin knockout in myeloid cells eliminates the enhanced healing effect.
- Findings challenge the traditional view that plasma fibronectin is solely liver-derived.
- LPMs serve as a source of circulating fibronectin, promoting matrix formation at distant sites.