Antibody-Drug Conjugates in Oncology: Principles, Clinical Development, and Future Directions - PubMed
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- ADCs target delivery of cytotoxic agents to tumors, improving therapeutic efficacy while minimizing side effects.
- Key components influencing ADC success include antibody engineering, linker stability, payload selection, and tumor antigen characteristics.
- Clinical applications in breast, lung, and uro-oncological cancers illustrate both benefits and challenges like drug resistance.
- Future directions focus on advanced technologies such as bispecific ADCs and strategies to overcome resistance.