The dual role of the crosstalk between autophagy and ferroptosis in lung cancer treatment: Advances in mechanisms and therapeutic strategies (Review) - PubMed
5 days ago
- #lung-cancer
- #autophagy
- #ferroptosis
- Autophagy and ferroptosis interaction offers new approaches for lung cancer (LC) treatment.
- Three core regulatory modes connect autophagy and ferroptosis: negative, positive, and feedback regulation.
- The interaction has a dual role in LC: promoting cancer cell survival and suppressing LC by inducing ferroptosis and immune clearance.
- Therapeutic strategies include repurposing traditional agents like chloroquine and developing small-molecule compounds targeting autophagy-ferroptosis crosstalk.
- Combination therapies with chemotherapy, radiotherapy, targeted therapy, and immunotherapy show synergistic potential.
- Challenges include complex regulatory mechanisms, inter-individual variability, and most strategies being in preclinical phases.
- Multi-omics technologies, precise biomarkers, AI, and big data are essential for advancing novel drugs and improving LC prognosis.