Effects of Acetyl-l-Carnitine on the Mitophagy in the Spinal Cord Injury Progression Through PINK/Parkin Pathway - PubMed
3 hours ago
- #spinal-cord-injury
- #neuroprotection
- #mitophagy
- Acetyl-l-Carnitine (ALC) shows neuroprotective effects in spinal cord injury (SCI) by promoting neuronal cell growth and inhibiting oxidative stress.
- ALC enhances mitophagy, a process that removes damaged mitochondria, through the PINK1/Parkin pathway in SCI models.
- In vitro and in vivo studies demonstrate ALC's ability to reduce apoptosis and oxidative stress in PC12 cells and SCI rats.
- The study suggests ALC's mechanism against SCI involves promoting mitophagy, offering potential therapeutic insights for SCI treatment.