FOXN3 integrates the KU70/KU80/SREBP-1 complex to regulate lipid metabolism in non-alcoholic fatty liver disease - PubMed
3 hours ago
- #FOXN3
- #NAFLD
- #lipid metabolism
- FOXN3 interacts with the KU70/KU80/SREBP-1 complex to regulate lipid metabolism in NAFLD.
- Hepatocyte-specific knockout of FOXN3 alleviates NAFLD progression by suppressing fatty acid and cholesterol synthesis.
- Phosphorylation of FOXN3 at S83 and S85 disrupts the KU70/KU80/FOXN3/SREBP-1 complex stability, impeding NAFLD progression.
- FOXN3, KU80, and SREBP-1 co-target lipogenic gene promoters in fatty liver tissues from patients.
- Reduced phosphorylation of FOXN3 at S83/S85 in fatty liver enhances FOXN3/SREBP-1 complex enrichment at lipogenic gene promoters.