Plasma p-tau217, p-tau181 and Aβ42/40 for Alzheimer's disease diagnosis: ROC accuracy and 18F-florbetapir amyloid PET-CT concordance - PubMed
8 hours ago
- #Alzheimer's disease
- #Biomarkers
- #Amyloid PET-CT
- Plasma biomarkers p-tau217, p-tau181, and Aβ42/40 ratio are evaluated for Alzheimer's disease (AD) diagnosis.
- Study includes 70 participants: 20 with mild cognitive impairment (MCI), 35 with AD, and 15 healthy controls (HC).
- Plasma Aβ42 levels and Aβ42/Aβ40 ratio were lower in AD patients, while p-tau181, p-tau217, GFAP, and NfL were higher.
- Aβ42/Aβ40 ratio positively correlated with MMSE scores; p-tau181, p-tau217, GFAP, and NfL negatively correlated.
- 18F-Florbetapir PET-CT amyloid imaging in 18 patients showed concordance with plasma biomarkers for amyloid detection.
- Combining Aβ42/Aβ40 ratio, p-tau181, and p-tau217 with GFAP and NfL may improve AD diagnostic accuracy.