Saquinavir induces pyroptosis through the OTUD5-JAK1-GSDME axis in hepatocellular carcinoma - PubMed
7 days ago
- #Saquinavir
- #Pyroptosis
- #Hepatocellular Carcinoma
- Saquinavir (SAQ) induces pyroptosis in hepatocellular carcinoma (HCC) via the OTUD5-JAK1-GSDME axis.
- SAQ inhibits HCC cell proliferation and triggers caspase-3-GSDME dependent pyroptosis.
- Mechanistically, SAQ blocks glucose metabolism, reduces lactate, and promotes ROS outburst.
- SAQ targets OTUD5, leading to JAK1 degradation, mitochondrial disruption, and pyroptosis activation.
- Combination of SAQ with sorafenib shows synergistic antitumor effects in vitro and in vivo.
- The study highlights SAQ as a novel pyroptosis-inducer and suggests new HCC treatment strategies.