REEP6 promotes colorectal cancer glycolysis and tumorigenesis through PRMT5-mediated PGAM1 arginine methylation - PubMed
8 days ago
- #colorectal-cancer
- #glycolysis
- #tumorigenesis
- REEP6 is significantly upregulated in colorectal cancer (CRC) and promotes glycolysis and tumorigenesis.
- REEP6 acts as a molecular scaffolder, bridging the PRMT5-PGAM1 complex, enhancing PRMT5-mediated symmetric dimethylarginine (SDMA) of PGAM1 at R40.
- Methylated PGAM1 shows dramatically enhanced enzymatic activity, boosting glycolytic flux in CRC cells.
- Combined treatment with specific shRNA and inhibitors exhibits synergistic anti-tumor efficacy in CRC, suggesting a promising therapeutic approach.