Impaired [Formula: see text]-Synuclein aggregate clearance in neuronal cells drive their spread to microglia through tunneling nanotubes - PubMed
7 hours ago
- #Autophagy
- #Tunneling Nanotubes
- #α-Synuclein
- Tunneling nanotubes (TNTs) facilitate intercellular communication and transfer of molecular cargoes, including α-Synuclein (α-Syn) aggregates.
- Microglia exhibit higher lysosomal turnover and efficient degradation of α-Syn aggregates, while neurons show compromised lysosomal and autophagic functions.
- Impaired autophagy in neurons leads to increased TNT-mediated transfer of α-Syn aggregates to microglia.
- Microglia co-cultured with α-Syn-containing neurons upregulate autophagy flux to degrade transferred aggregates effectively.
- The study highlights dysfunctional autophagy in neurons as a key factor in outsourcing α-Syn aggregates to microglia.