NUDT21 Drives T-Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation - PubMed
5 hours ago
- #T-ALL
- #NUDT21
- #Oncogenic Regulation
- NUDT21 is identified as a key factor in T-ALL maintenance, upregulated in patients and linked to poor outcomes.
- Mechanistically, NUDT21 promotes distal poly(A) site usage for oncogenic transcripts like UBE2D3, enhancing mRNA stability and protein expression, which drives proliferation via MYC signaling.
- NUDT21 also localizes to promoters, interacting with transcription factors (MYB, RUNX1, GATA3) to facilitate MYC transcription, extending its role beyond APA regulation.
- Pharmacological targeting with ouabain octahydrate induces apoptosis in T-ALL cells by degrading NUDT21 and suppressing UBE2D3 and MYC, highlighting it as a therapeutic target.