Bridging the gap: Prevotella/Segatella's impact on gut barrier function and advanced cultivation strategies to realize the uses in gut health - PubMed
4 hours ago
- #microbial therapeutics
- #gut barrier function
- #Prevotella
- Prevotella and Segatella are keystone genera in the gut microbiota with strong fiber-degrading abilities.
- They play a critical role in modulating gut microbial composition, host metabolic pathways, and gut barrier function.
- Their probiotic potential on epithelial barrier function has been largely overlooked despite their dominance in healthy gut microbiomes.
- The review explores their microbial eco-profiling and molecular mechanisms in sustaining intestinal barrier function across multiple dimensions.
- 23 current commercial and research-based isolation and cultivation approaches for Prevotella/Segatella are summarized, including high-throughput methodologies.
- Future research should focus on characterizing strain-specific functional profiles using multi-omics approaches for personalized microbial therapeutics.