Protective mutations associated with APOE in Alzheimer's disease - PubMed
4 days ago
- #Alzheimer's disease
- #APOE gene
- #neurodegenerative disorders
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder with increasing global incidence.
- The APOE gene, particularly the APOE4 allele, is a major genetic determinant of sporadic AD risk.
- Protective variants of APOE can reduce AD risk or delay its onset, offering potential for treatment development.
- The review examines APOE's protective effects and related mutations at the cellular level in AD pathology.
- Potential therapeutic strategies include gene editing, RNA editing, and stem cell therapy leveraging APOE protective variants.