Supplements and Drugs Are Associated With Biological Age in a Cohort of Exceptionally Healthy Individuals - PubMed
3 hours ago
- #epigenetic clock
- #biological aging
- #supplements
- The study analyzed data from 4,260 'health enthusiasts' who used saliva-based DNA epigenetic tests and completed lifestyle and supplement questionnaires.
- A proprietary 9-CpG epigenetic clock with a mean absolute error of 5.4 years was used to measure biological age.
- High supplement use (71% prevalence) in the cohort provided power to study supplement effects compared to general population studies.
- Delayed-release calcium-alpha-ketoglutarate (dAKG) with vitamins (Rejuvant) was associated with an average 1.8-year lower biological age (Age Residual) in cross-sectional analysis.
- Regular AKG use showed a smaller, statistically insignificant benefit compared to dAKG supplement.
- Among medications, antihistamine use had a non-significant benefit, limited by sample size.
- In a longitudinal subset, coenzyme Q10 (CoQ10) and dAKG intake were associated with increased odds of lower biological age, but results were not significant after multivariate correction.
- The study highlights the utility of saliva-based epigenetic tests for aging research and identifies AKG and CoQ10 as promising supplements for further investigation.
- Limitations include healthy user and recruitment bias, requiring future controlled trials to address.