Metabologenomic Hallmark-Based Discovery of Bacterial Thioamides as a New Lead against Drug-Resistant Pancreatic Cancer - PubMed
7 hours ago
- #pancreatic-cancer
- #thioamide
- #metabologenomic
- A metabologenomic method was developed to discover thioamide compounds in bacteria.
- Two new thioamides, thiogochangamides A and B, were discovered in Streptomyces sp.
- Thiogochangamide B shows potent activity against gemcitabine-resistant pancreatic cancer cells.
- The compound downregulates Wnt/β-catenin signaling, suppressing metastatic potential.
- The study offers a new strategy for treating drug-resistant pancreatic cancer.