Dimethyl fumarate and mitochondrial physiology: implications for neurological disorders - PubMed
4 hours ago
- #neurological disorders
- #dimethyl fumarate
- #mitochondria
- Dimethyl fumarate (DMF) is used to treat multiple sclerosis and plaque psoriasis.
- DMF influences cellular redox homeostasis and mitochondrial physiology.
- Mitochondria are crucial for neuronal survival and function.
- DMF activates the Nrf2 pathway, increasing antioxidant enzymes and mitochondrial biogenesis markers.
- In neurons and oligodendrocytes, DMF enhances respiratory function and limits apoptosis.
- DMF shows potential in disease models like Friedreich's ataxia and C9orf72-related disorders.
- In microglia, T cells, and vascular cells, DMF may impair mitochondrial respiration or increase apoptosis.
- DMF's effects on mitochondria are cell type-specific and context-dependent.
- Understanding DMF's mechanisms could optimize therapeutic strategies for neurological disorders.