DEUP1 functions as a scaffold for basal foot integrity and planar polarity in multiciliated cells - PubMed
3 hours ago
- #DEUP1
- #planar polarity
- #multiciliated cells
- DEUP1 is essential for basal foot integrity and planar polarity in multiciliated cells.
- DEUP1 localizes to the middle tier of the basal foot, adjacent to CNTRL.
- DEUP1 knockout disrupts basal foot architecture, leading to loss of rotational planar polarity and reduced cerebrospinal fluid flow.
- Ciliary degeneration occurs in aged DEUP1 knockout animals.
- DEUP1 does not affect basal body or cilia number in early or mature adult stages.
- The findings highlight DEUP1's role in long-term maintenance of coordinated ciliary motility.